Driving Biological Projects

In general, driving biological projects (DBPs) are expected to be early adopters of the Center's technology and collaborate broadly with the center's activities. They help stimulate new creative ideas and applications for its technology, and provide feedback on existing endeavors. The key personnel of DBPs attend center project meetings, participate in regular teleconferences, and contribute to all aspects of their respective center.

NCBO has collaborated with researchers in DBPs representing a broad range of biomedical research endeavors. These projects were selected for their scientific merit in answering important biomedical questions and advancing their disciplines.

Enabling systems immunology through ontological normalization and analysis of literature-based standards
Steven H. Kleinstein and Kei Cheung, Yale University School of Medicine
Ontology Driven Analysis and Profiling of High Throughput Data ArrayExpress
Helen Parkinson and James Malone, European Bioinformatics Institute


Synapse: A Precompetitive Space for Integrative Genomics
Mike Kellen and Stephen Friend, Sage Bionetworks
Analyzing Evidence in HIV Clinical Trials
Ida Sim, University of California, San Francisco
Linking Mutations in Drosophila to Human Disease
Michael Ashburner, University of Cambridge
Cancer Nanotechnology Knowledge Base for Nanoparticle Analysis and Design
David Paik, Stanford University, and Nathan Baker, Washington University
Accelerating Candidate Gene Discovery through Ontological Indexing of Large Scale Data Repositories
Simon Twigger, Human and Molecular Genetics Center, Medical College of Wisconsin
Ontology-Based Annotation of Time-Series Data
Raimond Winslow, Center for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University

The Center may be supporting additional driving biological projects and collaborating research activities. Please see How to Collaborate for information on potential avenues of collaboration, as well as NIH-Supported Opportunities for Collaboration for details on the Collaborating R01 and R21 Program for collaborating with the National Centers for Biomedical Computation.