Informatics for Integrating Biology and the Bedside (i2b2)

Isaac Kohane , Harvard Medical School                                   John Glaser, Partners HealthCare System

2b2 (Informatics for Integrating Biology and the Bedside) is an NIH-funded National Center for Biomedical Computing based at Partners HealthCare System. The i2b2 Center is developing a scalable informatics framework that will enable clinical researchers to use existing clinical data for discovery research and, when combined with IRB-approved genomic data, facilitate the design of targeted therapies for individual patients with diseases having genetic origins. This platform currently enjoys wide international adoption by the CTSA network, academic health centers, and industry.

Our collaborative activities with i2b2 have the following two specific aims:
(1) Integrate NCBO Web services to support the ontology needs of the i2b2 platform: For this aim, we are prototyping mechanisms to "pull" any ontology stored in BioPortal into the format used by i2b2's ontology cell. The goal is to ensure that users have access to the latest versions of ontologies as well as site specific view of ontologies for use within the i2b2 platform.
(2) Investigate the use of NCBO hosted mappings to enable efficient query translation in cross-institutional tools: For this aim, we are exploring mechanisms for using mappings for query translation via the Health Ontology Mapper (HOM) project. The goal is to use BioPortal as the shared repository for inter terminology mappings, which may be created and curated in a collaborative manner.